Transmission of Genetic Information. Genetic Mutations and Site-Directed Mutagenesis. Genomics and the Human Genome. Theoretical Aspects and Hardware. Crystallization and Crystal Habits. Theory and Determination of g-values.
Proteomics of Human Body Fluids. One of the major themes of the text—metals in medicine—is very well developed and will provide a valuable resource for new researchers to this area. Humana Press, , pp. A Short Course Rosette M. Theory and Determination of g-values.
Hyperfine and Superhyperfine Interactions. Nuclear Screening and the Chemical Shift.
Obtaining the NMR spectrum. Quadrupole Splitting and the Isomer Shift. Introduction to Computer-Based Methods. Molecular Modeling and Molecular Mechanics. Molecular Modeling Descriptive Examples. Quantum Mechanics-Based Computational Methods. Computer Software for Chemistry. World Wide Web Online Resources.
Nomenclature and Visualization Resources. Group I and II metals in biological systems. Transport and storage of metal ions.
Movement of molecules and ions across membranes. Active versus passive transport. Catalytic RNA and Magnesium.
Biochemistry of nitrogen oxides, nitroxyl, and peroxynitrite ion. Iron Containing Proteins and Enzymes. Iron-containing proteins with porphyrin ligand systems.
Hemoglobin and Myoglobin first edition material somewhat condensed. Iron-containing cytochromes in photosynthesis.
Iron-containing cytochromes in the respiratory pathway. Following the obligatory introductory chapters on the solution chemistry of metal ions, coordination chemistry, biochemistry, and physical methods, the author develops four topical chapters that include oxygen-binding proteins and models, copper enzymes, nitrogenase, and metals in medicine.
A strong structure—function perspective underlies each of these themes. Chapter 1 presents a fairly concise and adequate coverage of the structural, kinetic, and thermodynamic principles that are required for an understanding of biological coordination chemistry. Chapter 2 introduces key structural concepts in protein and nucleic acid chemistry and common molecular biology techniques. More recent ideas in genomics and proteomics are also introduced. The third chapter covers instrumental and computational methods with a major focus on structural techniques x-ray and nuclear magnetic resonance and modeling, and each method is supplemented by descriptive examples.
The sections on computer modeling provide a useful and comprehensive summary of the concepts and applications of available software.
Chapters 4 through 6 each offer a detailed description of a selected biological problem as well as a summary of research investigations of both the actual biological system and efforts to mimic or model the system through synthetic complexes. By the nature of the topic, chapter 7 Metals in Medicine requires a fusion of both approaches. Each chapter provides case studies that illustrate both concepts and methodologies and their applications.
Although valuable for the reader with some previous experience of the area, it is likely that undergraduates or beginning graduate students would require considerable guidance from an instructor to make their way through these discussions.
The writing in chapters 4 through 7 tends to be at a level that exceeds the preparative nature of the text, so it will be of most value for active researchers in bioinorganic chemistry rather than to an introductory audience. Because the subject matter falls either in the extremely introductory chapters 1—3 or advanced application categories chapters 4—7 , with little in the way of bridging material, it tends to lose focus on its intended target audience.
Overall, this book will provide a valuable resource for workers in the field.